ISOTOPES DON'T HAVE TO BE RADIOACTIVE to be used as tracers in clinical medicine and environmental studies. At next week's meeting of the APS Division of Atomic, Molecular, and Optical Physics, Daniel Murnick of Rutgers University (973-353-5446, murnick@newark.rutgers.edu) will describe how advances in optical spectroscopy are making stable isotopes a cost-effective and useful medical tool. For example, they have led to a fast, less expensive (and FDA-approved) breath test for gastrointestinal infections created by Helicobacter pylori, a bacterium which can cause duodenal ulcers and other disorders. In the test, a patient swallows a small dose of the organic compound urea, labeled with the isotope carbon-13. If the bacteria is present, they will break down the urea into ammonia and carbon dioxide containing C-13. Shortly thereafter, technicians collect the patient's exhaled breath, which has both C-13 and the more common isotope C-12. The breath samples enter a small cell containing a pair of electrodes. With electric current flowing between the electrodes, the breath is illuminated with an "isotope laser," a light source tuned to an energy transition in a specific isotope. By the "optogalvanic effect," the proper isotope will respond to the light and enter a different energy state, thereby changing the conductivity between the electrodes.
By monitoring the changes in current while alternately exciting C-13 and C-12 with different isotope lasers, the researchers can detect abnormally high C-13/C-12 ratios indicating the presence of H. pylori bacteria. Murnick will explain how this technique can also potentially be used for real-time monitoring of atmospheric CO2, present in concentrations 300 times less than that of a human breath. (Talk C2-1; meeting program.